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Histamine dihydrochloride
Histamine dihydrochloride (INN, trade name Ceplene) is a salt of histamine which is used as a drug for the prevention of relapse in patients diagnosed with acute myeloid leukemia (AML). It is an FDA approved〔http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/DevelopmentResources/Over-the-CounterOTCDrugs/StatusofOTCRulemakings/UCM077928.pdf〕 active ingredient for topical analgesic use and is available in such products as Australian Dream Cream, which is used for the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, bruises, sprains, and strains.〔http://www.australiandream.com/ingredients/〕
==Use in leukemia==
Histamine dihydrochloride is administered in conjunction with low doses of the immune-activating cytokine interleukin-2 (IL-2) in the post-remission phase of AML, i.e. when patients have completed the initial chemotherapy. This combination has been reported to significantly reduce the risk of relapse in AML. The effect is particularly pronounced in patients in their first remission who are below the age of 60.
The combination of histamine dihydrochloride and interleukin-2 was approved for use in AML patients within the European Union in October 2008〔Committee For Medicinal Products For Human Use: (Summary Of Positive Opinion for Ceplene ) (2008-11-25)〕 and will be marketed in the EU by the Swedish pharmaceutical company Meda. The drug is also available through a named patient program in several other countries (excluding the US).
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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